منابع مشابه
Gene Therapy Targeting HIV Entry
Despite the unquestionable success of antiretroviral therapy (ART) in the treatment of HIV infection, the cost, need for daily adherence, and HIV-associated morbidities that persist despite ART all underscore the need to develop a cure for HIV. The cure achieved following an allogeneic hematopoietic stem cell transplant (HSCT) using HIV-resistant cells, and more recently, the report of short-te...
متن کاملHIV Transmission, Entry, and Gene Therapy
For HIV to enter cells, the viral surface protein Envelope (Env) must sequentially bind the host protein CD4 and one of two coreceptors, either CCR5 or CXCR4. This triggers conformational changes in Env that result in fusion of the host and viral membranes. Our understanding of this process has led to the development of successful anti-viral drugs and provided insights into viral pathogenesis. ...
متن کاملConditional gene targeting for cancer gene therapy.
Current treatment of solid tumors is limited by severe adverse effects, resulting in a narrow therapeutic index. Therefore, cancer gene therapy has emerged as a targeted approach that would significantly reduce undesired side effects in normal tissues. This approach requires a clear understanding of the molecular biology of both the malignant clone and the biological vectors that serve as vehic...
متن کاملAAV-Based Targeting Gene Therapy
Since the first parvovirus serotype AAV2 was isolated from human and used as a vector for gene therapy application, there have been significant progresses in AAV vector development. AAV vectors have been extensively investigated in gene therapy for a broad application. AAV vectors have been considered as the first choice of vector due to efficient infectivity, stable expression and nonpathogeni...
متن کاملGene therapy for HIV.
Introduction With the advent of highly active antiretroviral therapy (HAART), the therapeutic landscape for HIV infected individuals has changed irrevocably. From what can be likened to a defensive approach to AIDS, juggling prophylactic therapies and treating opportunistic pathogens, HAART has taken us onto the oVensive, restoring a sense of optimism to physicians and patients alike in the dev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2014
ISSN: 1999-4915
DOI: 10.3390/v6031395